Websulfamethoxazole-trimethoprim oral increases toxicity of methotrexate by the drugs competing to be bound to protein and therefore possibly increasing the amount of the … WebTrimethoprim is a dihydropyrimidine antimicrobial and antiparasitic agent. It is the prototype of a group of nonsulfonamide drugs that inhibit dihydrofolate reductase in bacterial and protozoal cells. Although introduced as an antimalarial agent, it is now used primarily as an antibacterial agent, especially in combination with sulfamethoxazole ...

Trimethoprim Interactions BNF NICE

WebApr 12, 2024 · Methotrexate: try splitting your dose so you still take all the tablets within a 24 hour period. Alternatively, you could ask your GP to give you anti nausea tablets or you could contact us to discuss the possibility of changing from tablets to a Methotrexate injection. Leflunomide: Ask your GP to reduce to dose to 10mg daily. top rated exfoliator for face

Methotrexate and trimethoprim Interactions - Drugs.com

WebPrescribe trimethoprim with caution in the elderly and people: With impaired renal function. At risk of hyperkalaemia — monitor serum electrolytes closely. ... Methotrexate (a folate … WebKeywords: drug interaction, methotrexate, methotrexate toxicity, pancytopenia, trimethoprim–sulphamethoxazole SUMMARY What is known and Objective: Combining methotrexate (MTX) with trimethoprim-sulfamethoxazole (TS) is associated with a potential drug interaction that increases MTX toxicity. The aim WebBased upon the Naranjo probability scale score of 9, TMP–SMX was the probable cause of the patient’s hyponatremia. Conclusion: Our patient developed hyponatremia from TMP–SMX therapy upon initial use and rechallenge. Although hyponatremia appears to be rare with TMP–SMX therapy, providers should be aware of this potentially life ... top rated exotic movie