Mechanisms of resistance to cisplatin
WebJul 28, 2024 · Inside the tumor cell, decreased drug import, increased drug export, increased drug inactivation by detoxification enzymes, increased DNA damage repair, and inactivated cell death signaling are major mechanisms leading to cisplatin resistance. WebMar 17, 2016 · The majority of ovarian tumors eventually recur in a drug resistant form. Using cisplatin sensitive and resistant cell lines assembled into 3D spheroids we profiled gene expression and identified candidate mechanisms and biological pathways associated with cisplatin resistance. OVCAR-8 human ovarian carcinoma cells were exposed to sub …
Mechanisms of resistance to cisplatin
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WebJul 1, 2001 · Mechanisms of resistance to cisplatin. The use of cisplatin in cancer chemotherapy is limited by acquired or intrinsic resistance of cells to the drug. Cisplatin enters the cells and its chloride ligands are replaced by water, forming aquated species that react with nucleophilic sites in cellular macromolecules. WebAug 24, 2024 · Components of tumor microenvironment reported to affect cisplatin resistance. These components can contribute to cisplatin resistance through decreased …
WebThe intracellular targets and mechanisms of action/resistance of oxaliplatin differ from that of its predecessors, cisplatin and carboplatin. It is important to note that oxaliplatin is more active in colon cells [ 6 ], and that cisplatin-resistant cell lines are sensitive to oxaliplatin [ 7, 8 ]. Intracellular targets and mechanisms of action WebJan 20, 2024 · Therefore, revealing the underlying mechanisms of chemotherapy resistance in LSCC and identifying novel biomarkers for targeted therapy are urgently required to improving the dismal outcome of this disease. ... Upregulation of FOXD2-AS1 enhanced cisplatin resistance of laryngeal cancer cells in vitro.
WebSep 24, 2024 · Cisplatin exerts anticancer activity via multiple mechanisms. Its most acceptable mechanism involves the formation of DNA–platinum adducts by interacting … WebThe first is the reduction in the accumulation of the drug intracellular. 17 Reduced accumulation of drug is a significant mechanism that results into resistance and reductions in accumulation of drugs by a factor of between 20% to70% could cause resistance of cisplatin by a factor of 3 to 40 fold respectively. 18 However as Koberle et al ...
WebFeb 28, 2024 · However, the principal mechanisms by which 13 and, above all, 18 overcome cisplatin resistance rely on three different possible mechanisms: the inhibition of …
WebPDF) Review on Pharmacology of Cisplatin: Clinical Use, Toxicity and Mechanism of Resistance of Cisplatin ResearchGate. PDF) Cisplatin: An old drug with a newfound efficacy – from mechanisms of action to cytotoxicity. CyberLeninka. On the Discovery, Biological Effects, and Use of Cisplatin and Metallocenes in Anticancer Chemotherapy – topic ... lakewood national homes for sale floridaWebMar 22, 2024 · EMT-associated chemotherapy resistance in SCC. To investigate the role and the mechanisms of resistance to therapy in EMT tumour cells in vivo, we used a genetically induced mouse model of skin SCCs combining the expression of oncogenic Kras (Kras G12D) with the deletion of Trp53 and the expression of a YFP reporter in hair follicle … helly hansen westport jacketWebAug 1, 2001 · Knowledge of the mechanism of action of cisplatin has improved our understanding of resistance. Decreased intracellular concentration due to decreased drug uptake, increased reflux or... lakewood national golf community bradenton flWebMechanisms of resistance to cisplatin Alan Eastman Chapter 115 Accesses 29 Citations Part of the Cancer Treatment and Research book series (CTAR,volume 57) Abstract … lakewood national homes for sale lennarhttp://connectioncenter.3m.com/cisplatin+research+paper helly hansen westin whistlerWebNov 15, 1987 · Differential expression of collateral sensitivity or resistance to cisplatin in human bladder carcinoma cell lines pre-exposed in vitro to either X-irradiation or cisplatin ... was significantly elevated at later times. These findings suggest that mechanisms associated with the expression of resistance and collateral sensitivity to cisplatin ... helly hansen w crew vestWebJul 28, 2024 · Although cisplatin has been a pivotal chemotherapy drug in treating patients with various types of cancer for decades, drug resistance has been a major clinical … helly hansen which country