Nettet9. jun. 2010 · PAH, probenecid, piroxicam, octanoate, and citrinin inhibited [3 H]OTA uptake by hOAT1 and hOAT3 in a competitive manner (K i: 4.29-3080 µM), with different orders of potency for hOAT1 and for hOAT3. These results indicate that hOAT1and hOAT3 both mediate the high-affinity transport of OTA on the basolateral side of the … Nettet1. mai 2002 · Immunofluorescence localization of hOAT3 in the human kidney. hOAT3 (A) and F-actin (B) in the same section. The brush border membrane of the proximal tubules clearly showed F-actin staining ...
Human Organic Anion Transporters 1 (hOAT1/SLC22A6) and 3 …
NettethOAT3は,エ ストロンサルフェートがhOAT3輸 送体のみで分泌輸送されると仮定するとヒト女性 エストロンサルフェート血清濃度2.78nM,尿 中 1日 排泄量7.90ug/か ら換算するとhOAT3を 介し た尿酸輸送量は尿酸の糸球体濾過量の約0.1倍 程 度となる13). Nettet1. aug. 2002 · In conclusion, these results suggest that methotrexate is taken up via hOAT3 and hOAT1 at the basolateral side of the proximal tubule and effluxed or taken up at the apical side via hOAT4. In addition, hOAT1, hOAT3, and hOAT4 are the sites of drug interactions between methotrexate and NSAIDs, probenecid, and penicillin G. dunk low washed teal images
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Nettet15. feb. 2024 · Firstly, to identify whether piperacillin and tazobactam were the substrates of hOAT1 or hOAT3, the time profiles of piperacillin and tazobactam uptake by hOAT1/3-HEK293 cells were investigated. The uptakes of piperacillin (Fig. 4 A and B) and tazobactam (Fig. 4 C and D) in hOAT1/3-HEK293 cells were higher compared with … Nettet1. nov. 2004 · Human organic anion transporters hOAT1 (SLC22A6) and hOAT3 (SLC22A8) are responsible for renal tubular secretion of an antifolic acid methotrexate, … Nettet5. nov. 2012 · Transporter-mediated drug-drug interactions in the kidney dramatically influence the pharmacokinetics and other clinical effects of drugs. Human organic anion … dunk low white and sail